张家祥,男,中共党员,医学博士,副教授,硕士研究生导师,兼任中国环境诱变剂学会生物标志物专业委员会青年委员,安徽省预防医学会职业卫生与职业病专业委员会常务委员,安徽省医师协会变态反应医师分会常务委员,安徽省环境诱变剂学会理事,安徽省职业健康安全协会职业卫生与放射卫生分会委员。近年来先后主持国家自然科学基金项目2项,安徽省自然科学基金青年项目、beat365官方网站博士科研项目和beat365官方网站校科研基金,作为主要成员参与国家自然科学基金及省部级课题多项,主持省质量工程项目教学项目2项(空气理化检验在线课程和教学研究项目各1项),在国内外期刊发表学术论文60余篇,荣获安徽省科学技术奖1项,beat365官方网站2023年度优秀教师,beat365官方网站2022年復元科技新星,beat365官方网站2018年度科技新星称号,参编安徽大学出版社《预防保健学》(第3、4版)兼任编委会秘书。
主要研究和招生方向:职业性有害因素暴露与免疫损伤
联系邮箱:jiaxiang5337@126.com
1.主持的科研项目
[1]国家自然科学基金项目,82273602,2023.01-2026.12,主持
[2]国家自然科学基金项目,81502791,2016.01-2018.12,主持
[3]安徽省自然科学基金项目,2008085QH385,2020.07-2022.06,主持
2.主持和参与的教研项目
[1]空气理化检验线上课程(原MOOC)(2020mooc198),省级质量工程项目,主持
[2]基于OKR评估方法的《职业卫生与职业医学》教学模式探究(2021jyxm0676),省级质量工程项目,主持
[3]医疗卫生人员职业卫生与防护(xjmooc31),校级大规模在线开放课程(MOOC)示范项目,参与人
[4]空气理化检验(xjzxkfkc51),校级大规模在线开放课程(MOOC)示范项目,参与人
3. 近5年代表性论文
[1]Xu Y, Chu C, Shi Z, Zhang J*.The role of hepatocyte mitochondrial DNA in liver injury. Biomed Pharmacother. 2023;168:115692.
[2]Ding B, Zhou S, Wang Z, Liu W, Gao L, Ding Y, Huang H, Zhu Q*, Zhang JX*.Macrophage autophagy contributes to immune liver injury in trichloroethylene sensitized mice: Critical role of TNF-α mediating mTOR pathway. J Cell Physiol. 2023 Jul 25.
[3]Zhang J#, Yang Y#, Huang H#, Xie HB, Huang M, Jiang W, Ding BW, Zhu QX*.TNF-α/TNFR1 regulates the polarization of Kupffer cells to mediate trichloroethylene-induced liver injury[J]. Ecotoxicol Environ Saf,2022,230:113141.
[4]Liu ZY, Jiang HZ, Wang L, Chen MX, Wang HT, Zhang JX*. Diagnostic accuracy of red blood cell distribution width for neonatal sepsis. Minerva Pediatr,2022,74(2):202-212.
[5]Xie H, Peng J, Zhang X, Deng L, Ding Y, Zuo X, Wang F, Wu Y, Zhang J*, Zhu Q*. Effects of mitochondrial reactive oxygen species-induced NLRP3 inflammasome activation on trichloroethylene-mediated kidney immune injury[J]. Ecotoxicol Environ Saf,2022,244:114067.
[6]Liu Z, Ma J, Zuo X, Zhang X, Hong Y, Cai S, Huang H, Wang F, Wu C, Zhang J*, Zhu Q*.C5b-9 mediates ferroptosis of tubular epithelial cells in trichloroethylene -sensitization mice. Ecotoxicol Environ Saf,2022,244:114020.
[7]Zuo X, Liu Z, Ma J, Ding Y, Cai S, Wu C, Zhang J*, Zhu Q*. Wnt 5a mediated inflammatory injury of renal tubular epithelial cells dependent on calcium signaling pathway in Trichloroethylene sensitized mice[J]. Ecotoxicol Environ Saf.2022.114019.
[8]Zhang X, Duan Y, Ma J, Liu Z, Ding Y, Xie H, Peng J, Wang F, Zhang J*, Zhu Q*. Trichloroethylene induces immune renal tubular injury through SIRT 1/HSP 70/TLR 4 pathway in BALBc mice[J]. Int Immunopharmacol.2022,112:109203.
[9]Liang B#, Huang H#, Zhang J#, Chen G, Kong X, Zhu M, Wang P, Tang L. Case Report: Chanarin-Dorfman Syndrome: A Novel Homozygous Mutation in ABHD5 Gene in a Chinese Case and Genotype-Phenotype Correlation Analysis[J]. Front Genet.2022,13:847321.
[10]Xie H, Zhang X, Peng J, Deng L, Wang F, Zhang J*, Zhu Q*. Endothelin-1 down-regulated vascular endothelial growth factor A is involved in trichloroethene-induced kidney injury[J]. Toxicol Ind Health.2022,38(5):287-298.
[11]Xie H, Wang H, Wu Q, Peng JL, Huang H, Wang Y, Huang M, Jiang W, Yang Y, Zhang X, Zhang J*, Zhu Q*. Endothelin-1/Endothelin Receptor Type A-Angiopoietins/Tie-2 Pathway in Regulating the Cross Talk Between Glomerular Endothelial Cells and Podocytes in Trichloroethylene-Induced Renal Immune Injury.J Inflamm Res.2021,14:761-776
[12]Zhang J#, Li N#, Xu QY, Yang Y, Xie HB, Shen T*, Zhu QX*. Kupffer cell depletion attenuates IL-6/STAT3 mediates hepatocyte apoptosis in immunological liver injury of trichloroethylene sensitized mice. Int Immunopharmacol.2020,88:106897.
[13]Zhang J, Xu QY, Yang Y, Li N, Zhang Y, Yang P, Deng LH, Zhu QX*, Shen T*. Kupffer cell inactivation ameliorates immune liver injury via TNF-α/TNFR1 signal pathway in trichloroethylene sensitized mice.Immunopharmacol Immunotoxicol.2020,13:1-11.
[14]Zhang J, Li N, Yang L, Xie H, Yang Y, Wang H, Wu C, Shen T*, Zhu Q*, Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: a role in Kupffer cell activation. Toxicology, 2019,415:37-48.
[15]Zhang J#, Li N#, Yang L#, Zang D, Yang P, Wang H, Shen T*, Zhu QX*, Role of selective blocking of bradykinin B1 receptor in attenuating immune liver injury in trichloroethylene-sensitized mice. Cytokine, 2018,108:71-81.
[16]Liu M#, Wang H#, Zhang J#, Yang X, Li B, Wu C, Zhu QX*, NF-κB signaling pathway-enhanced complement activation mediates renal injury in trichloroethylene-sensitized mice.J Immunotoxicol, 2018,15(1):63-72.
[17]百旺, 黄华, 杨呓, 丁雅妮, 朱启星*, 张家祥*. TNF-α/TNFR1抑制M1型Kupffer细胞自噬在三氯乙烯致敏小鼠肝损伤中的作用[J]. 中华劳动卫生职业病杂志,2022,40(05):321-327.
[18]左绪磊, 丁百旺, 黄华, 丁雅妮, 马金茹, 黄韵, 张家祥*, 朱启星*. 三氯乙烯所致小鼠免疫性肝损伤中TNF-α/TNFR1介导的WNT5A表达[J].中国职业医学,2022,49(01):15-21.
[19]黄华,丁百旺,左绪磊,杨呓,彭家乐,王燚灿,张家祥*,朱启星*. 经口暴露三氯乙烯对小鼠肝脏 JMJD3表达和 M1型库普弗细胞极化的影响 [J]. 环境与职业医学,2022,39(1):65-70.
[20]刘志远, 张家祥*, 朱启星. 职业性三氯乙烯药疹样皮炎的治疗策略[J].中国工业医学杂志, 2020, 33(4):319-322.
[21]张家祥, 许述海, 叶向光, 陆晓彤, 沈彤, 朱启星*. 轮胎制造行业噪声作业工人听力损失及相关因素分析[J].中国职业医学,2018,45(6):801-804.
(#共同第一作者,*通讯作者)